【J9官网 J9基因检测】骨科疾病筛查项目招标中关于DRD1的问题

基因检测的序列名称：

DRD1

人体基因序列变化与疾病表征数据库中的基因代码：

1812

人体基因序列数据库中国际研讨名称全称

dopamine receptor D1

中国数据库中基因全称：

多巴胺受体D1

基因检测报告英文版基因简介

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

基因突变所影响的基因信息

该基因编码多巴胺受体的D1亚型。D1亚型是中枢神经系统中贼丰富的多巴胺受体。这种G蛋白偶联受体刺激腺苷酸环化酶并激活环状AMP依赖性蛋白激酶。D1受体调节神经元的生长和发育，介导某些行为反应，并调节多巴胺受体D2介导的事件。交替的转录起始位点导致该基因的两个转录变体。[由RefSeq给予，2008年7月]

国际国内该碱基基因序列的其他英语文字母简称：

DADRA, DRD1

基因解码对该基因序列在细胞核中的染色体所给予的编号：

该基因序列位于人类第5号染色体上。

基因解码对基因序列的正确定位

该基因序列在GRCh37版本中的起始位置坐标为：174867675；结束位置坐标为：174871163。该基因序列在GRCh38版本中的起始位置坐标为：175440672；结束位置坐标为：175444160。正确的基因信息定位是基因检测和对检测结果进行正确解读的关键。

J9官网 J9基因解码对该基因的功能分类：国际版

G-protein coupled receptors/GPCRs excl olfactory receptors

基因解码对该基因的功能分类：中文版

G 蛋白偶联受体/GPCR 不包括嗅觉受体

结构与功能基因解码所揭示的该基因在细胞内发挥作用的场所（国际版）：

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结构与功能基因解码所揭示的该基因发挥作用的细胞内位置（中文版）：

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该基因序列变化后增加的疾病风险（国际版）：

Psychoses, Drug; Recurrent depression; Catalepsy; Dyskinesia, Drug-Induced; Movement Disorders; Parkinson Disease; Amphetamine-Related Disorders; Hypotension; Hyperactive behavior; Cocaine-Related Disorders; Mental Depression; Autistic Disorder; Alcoholic Intoxication, Chronic; Depressive disorder; Bipolar Disorder; Seizures; Schizophrenia

如果该基因突变后，风险可能增加的疾病类型（中文版）：

精神病药物；反复性抑郁症；僵住症；运动障碍药物引起的；运动障碍；帕金森综合症;苯丙胺相关疾病；低血压;多动行为；可卡因相关疾病；精神抑郁症；自闭症；酒精中毒慢性；抑郁症；躁郁症;癫痫发作；精神分裂症

GWAS基因检测所建立的与该基因的疾病关联（国际版）：

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GWAS基因检测所解码的该基因突变会增加风险的疾病种类（中文版）：

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以该基因做靶点的药物（国际版）：

Ziprasidone (G-protein coupled amine receptor activity);Cabergoline (G-protein coupled amine receptor activity);Cabergoline (G-protein coupled amine receptor activity);Ropinirole (G-protein coupled amine receptor activity);Olanzapine (G-protein coupled amine receptor activity);Olanzapine (G-protein coupled amine receptor activity);Methylergometrine (G-protein coupled amine receptor activity);Clozapine (G-protein coupled amine receptor activity);Mirtazapine (G-protein coupled amine receptor activity);Thiethylperazine (G-protein coupled amine receptor activity);Phenylpropanolamine (G-protein coupled amine receptor activity);Loxapine (G-protein coupled amine receptor activity);Loxapine (G-protein coupled amine receptor activity);Pramipexole (G-protein coupled amine receptor activity);Promazine (G-protein coupled amine receptor activity);Imipramine (G-protein coupled amine receptor activity);Chlorpromazine (G-protein coupled amine receptor activity);Chlorpromazine (G-protein coupled amine receptor activity);Haloperidol (G-protein coupled amine receptor activity);Triflupromazine (G-protein coupled amine receptor activity);Amoxapine (G-protein coupled amine receptor activity);Cinnarizine (G-protein coupled amine receptor activity);Lisuride (G-protein coupled amine receptor activity);Fluphenazine (G-protein coupled amine receptor activity);Thioridazine (G-protein coupled amine receptor activity);Ergotamine (G-protein coupled amine receptor activity);Apomorphine (G-protein coupled amine receptor activity);Trimipramine (G-protein coupled amine receptor activity);Risperidone (G-protein coupled amine receptor activity);Propiomazine (G-protein coupled amine receptor activity);Fenoldopam (G-protein coupled amine receptor activity);Minaprine (G-protein coupled amine receptor activity);Perphenazine (G-protein coupled amine receptor activity);Flupentixol (G-protein coupled amine receptor activity);Dopamine (G-protein coupled amine receptor activity);Dopamine (G-protein coupled amine receptor activity);Carphenazine (G-protein coupled amine receptor activity);Ergoloid mesylate (G-protein coupled amine receptor activity);Acetophenazine (G-protein coupled amine receptor activity);Pergolide (G-protein coupled amine receptor activity);Bromocriptine (G-protein coupled amine receptor activity);Quetiapine (G-protein coupled amine receptor activity);Levodopa (G-protein coupled amine receptor activity);Aripiprazole (G-protein coupled amine receptor activity);Chlorprothixene (G-protein coupled amine receptor activity);Paliperidone (G-protein coupled amine receptor activity);Methotrimeprazine (G-protein coupled amine receptor activity);Propericiazine (G-protein coupled amine receptor activity);Acepromazine (G-protein coupled amine receptor activity);Pipotiazine (G-protein coupled amine receptor activity);Thioproperazine (G-protein coupled amine receptor activity);Thiothixene (G-protein coupled amine receptor activity);Zuclopenthixol (G-protein coupled amine receptor activity);Iloperidone (G-protein coupled amine receptor activity);Rotigotine (G-protein coupled amine receptor activity);intranasal apomorphine (G-protein coupled amine receptor activity);Mianserin (G-protein coupled amine receptor activity);Asenapine (G-protein coupled amine receptor activity)

针对该基因所产生的突变，可能有正确效果的药物（中文版）：

齐拉西酮（G蛋白偶联胺受体活性）；卡麦角林（G蛋白偶联胺受体活性）；卡麦角林（G蛋白偶联胺受体活性）；罗匹尼罗（G蛋白偶联胺受体活性）；奥氮平（G蛋白偶联受体活性）胺受体活性);奥氮平(G-蛋白偶联胺受体活性);甲基麦角新碱(G-蛋白偶联胺受体活性);氯氮平(G-蛋白偶联胺受体活性);米氮平(G-蛋白偶联胺受体活性);硫乙拉嗪(G-蛋白偶联胺受体活性);苯丙醇胺(G-蛋白偶联胺受体活性);洛沙平(G-蛋白偶联胺受体活性);洛沙平(G-蛋白偶联胺受体活性);普拉克索(G-蛋白偶联胺受体活性)受体活性);丙嗪(G-蛋白偶联胺受体活性);丙咪嗪(G-蛋白偶联胺受体活性);氯丙嗪(G-蛋白偶联胺受体活性);氯丙嗪(G-蛋白偶联胺受体活性);氟哌啶醇( G-蛋白偶联胺受体活性);三氟丙嗪(G-蛋白偶联胺受体活性);阿莫沙平(G-蛋白偶联胺受体活性);桂利嗪(G-蛋白偶联胺受体活性);麦角乙脲(G-蛋白偶联胺受体活性)活性);氟奋乃静(G-蛋白偶联胺受体活性);硫利达嗪(G-蛋白偶联胺受体活性);麦角胺(G-蛋白偶联胺受体活性);阿扑吗啡(G-蛋白偶联胺受体活性);曲米帕明(G -蛋白偶联胺受体活性);利培酮(G-蛋白偶联胺受体活性);丙哌嗪(G-蛋白偶联胺受体活性);非诺多泮(G-蛋白偶联胺受体活性);米那普林(G-蛋白偶联胺受体活性) );奋乃静（G-蛋白偶联胺受体活性）;氟哌噻吨（G-蛋白偶联胺受体活性）;多巴胺（G-蛋白偶联胺受体活性）;多巴胺（G-蛋白偶联胺受体活性）;卡奋乃静（G-蛋白偶联胺受体活性）；麦角灵甲磺酸盐（G 蛋白偶联胺受体活性）；乙酰吩嗪（G 蛋白偶联胺受体活性）；培高利特（G 蛋白偶联胺受体活性）；溴隐亭（G 蛋白偶联胺受体活性） );喹硫平(G-蛋白偶联胺受体活性);左旋多巴(G-蛋白偶联胺受体活性);阿立哌唑(G-蛋白偶联胺受体活性);氯丙噻吨(G-蛋白偶联胺受体活性);帕利哌酮(G-蛋白偶联胺受体活性);甲氧美拉嗪(G-蛋白偶联胺受体活性);丙哌哌嗪(G-蛋白偶联胺受体活性);乙酰丙嗪(G-蛋白偶联胺受体活性);哌噻嗪(G-蛋白偶联胺受体活性) ;Thioproperazine (G-protein coupled amine receptor activity);Thiothixene (G-protein coupled amine receptor activity);Zuclopenthixol (G-protein coupled amine receptor activity);Iloperidone (G-protein coupled amine receptor activity);Rotigotine (G-protein coupled amine receptor activity)偶联胺受体活性）；鼻内阿扑吗啡（G 蛋白偶联胺受体活性）；米安色林（G 蛋白偶联胺受体活性）；阿塞那平（G 蛋白偶联胺受体活性）

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